NIH Awards $1.5 Million Grant for Blood Substitute Research
The National Institutes of Health recently awarded a $1.5 million grant to a University at Buffalo researcher to continue development of a possible inorganic blood substitute.
Dr. Claes Lundgren received the grant to continue studying the fluorocarbon-based compound dodecaflouropentane emulsion (DDFPe). DDFPe was originally used as a medium to provide contrast in taking ultrasound pictures. DDFPe is being investigated as a blood substitute because it is able to pass safely through capillaries while also being an effective oxygen transport mechanism.
Previous research in pigs has already demonstrated DDFPe’s promise. In a press release, Lundgren said,
We know that if it is administered soon after blood loss, the product has a dramatic effect. Very small amounts introduced into the circulation of a pig after severe blood loss can save the animal from hemorrhagic shock.
Lundgren’s grant will allow him to do research in animal models to determine how soon DDFPe has to be administered after bleeding begins and whether DDFPe can delay hemorrhagic shock for longer periods of time. Data from these experiments could move the possibility of a workable blood substitute closer. According to Lundgren,
Our findings should help to lay a solid foundation for pursuing FDA approval for human use of this blood substitute. In the best of circumstances, it would be carried in every ambulance.
Source:
Work on promising inorganic blood substitute to move forward with $1.5 million grant from NIH. Press Release, University at Buffalo, April 15, 2004.
Tags: Medical Research, Pigs